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What can we learn about cardioprotection from the cardiac mitochondrial proteome?

Marjan Gucek, Elizabeth Murphy
DOI: http://dx.doi.org/10.1093/cvr/cvq277 211-218 First published online: 30 August 2010

Abstract

This review will summarize proteomic methods that are useful in studying the role of mitochondria in cardioprotection. The strengths and weaknesses of some of the different approaches are discussed. We focus on the cardiac mitochondrial proteome with emphasis on changes associated with cell death and protection, and we summarize how proteomic data have contributed to addressing the role of mitochondria in cardioprotection.

  • Mitochondria
  • Cardioprotection
  • Phosphorylation
  • S-nitrosylation
  • Proteome
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