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Increase in myocardial oxygenation with propranolol

Arthur J. Moss , James Johnson , James Sentman
DOI: http://dx.doi.org/10.1093/cvr/4.4.441 441-442 First published online: 1 October 1970

Authors' synopsis

Intravenous propranolol, 0·25 mg/kg, significantly increased intramyocardial oxygen tension by 3 mm Hg (from 9 to 12 mm Hg) at a time when there was no change in coronary venous pO2. Propranolol appears to augment myocardial oxygen availability by decreasing the metabolic oxygen requirement of the heart in association with a reduction in cardiac work. It is concluded that propranolol has a rational physiological basis for use in the treatment of angina pectoris.

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