OUP user menu

Angiotensin II signal transduction and the mitogen-activated protein kinase pathway

Jennifer L. Duff, Mario B. Marrero, William G. Paxton, Bernhard Schieffer, Kenneth E. Bernstein, Bradford C. Berk
DOI: http://dx.doi.org/10.1016/S0008-6363(95)00088-7 511-517 First published online: 1 October 1995


In this review, the angiotensin-II-mediated signal transduction pathways involved in vascular smooth muscle cell growth are discussed. Classical pathways involving phospholipase C and protein kinase C, as well as the mitogen-activated protein kinase pathway, are common signal transduction pathways activated by a variety of growth factors to stimulate cell growth. Besides its vasoconstrictor activity, angiotensin II stimulates hypertrophy of vascular smooth muscle cells and is involved in neointimal proliferation following balloon angioplasty. Understanding angiotensin-II-stimulated signaling events, as well as the crosstalk among signaling pathways, may form the basis for the development of new therapies for hypertension and restenosis.

  • Angiotensin II
  • MAP kinase
  • Vascular smooth muscle
  • Hypertrophy
  • Signal transduction
  • Protein kinase C

    Sign in

    ESC members click here if your subscription is as an ESC Congress delegete or via your membership link.  Discover if you are an ESC member here.
    Note: after sign in you will be redirected to the journal's home page. 'ESC member' will display at the top of the page to indicate you have full access rights for this session.

    Otherwise, if your subscription is via OUP, enter your OUP username and password, or select an alternative sign in option below.

    Log in through your institution