OUP user menu

The effects of long term administration of prazosin on the microcirculation in skeletal muscles

DOI: http://dx.doi.org/10.1093/cvr/23.11.913 913-920 First published online: 1 November 1989


The effect on the microcirculaton of long term administration of the α1 blocker prazosin, which increases peripheral blood flow, was studied in skeletal muscles with differing metabolic profiles. Prazosin (50 mg·litre−1), given ad libitum for 5 weeks in the drinking water, resulted in an increase in capillarity in both fast glycolytic tibialis anterior cortex and slow oxidative soleus muscles of the rat. In tibialis anterior, the velocity of red blood cells through capillaries was increased, a smaller proportion of capillaries had intermittent flow, less time was spent stationary by red blood cells, and hence the calculated volume flow per capillary was increased. In soleus, capillary diameters were larger, but velocity, intermittency and calculated volume flow were unchanged. Therefore, suggested mechanisms for capillary growth induced by prazosin are different for the two muscles studied: increased shear stress and blood/endothelial cell interaction in the case of tibialis anterior, and increased capillary wall tension in the soleus.

Key words
  • red cell velocity
  • slow and fast muscle
  • capillary growth
  • rat
  • leucocyte adherence
  • intermittency of flow

    Sign in

    ESC members click here if your subscription is as an ESC Congress delegete or via your membership link.  Discover if you are an ESC member here.
    Note: after sign in you will be redirected to the journal's home page. 'ESC member' will display at the top of the page to indicate you have full access rights for this session.

    Otherwise, if your subscription is via OUP, enter your OUP username and password, or select an alternative sign in option below.

    Log in through your institution