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Cardiovascular Research Advance Access [Accepted Manuscript] published online on May 15, 2009
Cardiovascular Research, doi:10.1093/cvr/cvp151
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Regulation and pharmacology of the mitochondrial permeability transition pore

Dmitry B. Zorov, Magdalena Juhaszova, Yael Yaniv, H. Bradley Nuss, Su Wang and Steven J. Sollott

Laboratory of Cardiovascular Science, Gerontology Research Center, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA

Address for correspondence: Steven J. Sollott, M.D., Laboratory of Cardiovascular Science, Gerontology Research Center, Box 13, Intramural Research Program, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, Maryland 21224-6825, USA. Phone: (410) 558-8657; Fax: (410) 558-8150; E-mail: sollotts{at}mail.nih.gov

The "mitochondrial permeability transition," characterized by a sudden induced change of the inner mitochondrial membrane permeability for water as well as for small substances (≤ 1.5 kDa), has been known for three decades. Research interest in the entity responsible for this phenomenon, the "mitochondrial permeability transition pore" (mPTP) has dramatically increased after demonstration that it plays a key role in the life and death decision in cells. Therefore, a better understanding of this phenomenon and its regulation by environmental stresses, kinase signaling, and pharmacological intervention is vital. The characterization of the molecular identity of the mPTP will allow identification of possible pharmacologic targets and assist in drug design for its precise regulation. However, despite extensive research efforts, at this point the pore-forming core component(s) of the mPTP remain unidentified. Pivotal new genetic evidence has shown that components once believed to be core elements of the mPTP (namely, mitochondrial adenine nucleotide translocator and cyclophilin D) are instead only mPTP regulators (or in the case of voltage dependent anion channels, probably entirely dispensable). This review provides an update on the current state of knowledge regarding the regulation of the mPTP.

Time for primary review: 13 Days


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