Skip Navigation



Cardiovascular Research Advance Access [Accepted Manuscript] published online on April 27, 2009
Cardiovascular Research, doi:10.1093/cvr/cvp129
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
83/2/234    most recent
cvp129v2
cvp129v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Granfeldt, A.
Right arrow Articles by Vinten-Johansen, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Granfeldt, A.
Right arrow Articles by Vinten-Johansen, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Protective Ischemia in Patients: Preconditioning and Postconditioning

Asger Granfeldt1, David J. Lefer2 and Jakob Vinten-Johansen2

1 The Department of Anesthesiology and Critical Care, Aarhus University, Aarhus, Denmark
2 The Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory Crawford Long Hospital, Emory University School of Medicine, Atlanta, Georgia

Corresponding author: Jakob Vinten-Johansen, PhD, Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, 550 Peachtree Street NE, Atlanta, Georgia 30308-2225 USA, Phone: 404-686-2511, Fax: 404-686-4888, e-mail: jvinten{at}emory.edu

Infarct size can be limited by reducing the determinants of infarct size or increasing collateral blood flow by treatment initiated before the ischemic event. Reperfusion is the definitive treatment for permanently reducing infarct size and restoring some degree of contractile function to the affected myocardium. Innate survival mechanisms in the heart can be stimulated by short, non-lethal periods of ischemia and reperfusion, applied either before or after the ischemic event. Preconditioning, a series of transient intervals of ischemia and reperfusion applied before the lethal "index" ischemic event, sets in motion molecular and cellular mechanisms that increase cardiomyocyte survival to a degree that had not hitherto been seen before. The cardioprotective ischemic-reperfusion protocol applied at onset of reperfusion, termed "postconditioning", is also associated with significant cardioprotection that can be applied at the point of reperfusion treatment in the catheterization laboratory or operating room. Both preconditioning and postconditioning have been successfully applied to the clinical setting and have been found to reduce infarct size and other attributes of postischemic injury. This review will summarize the physiological preclinical data on preconditioning and postconditioning that are relevant to their translation to clinical therapeutics and treatment.

KEYWORDS preconditioning; postconditioning; infarct size; myocardial protection; coronary intervention; cardiac surgery

Time for primary review: 23 Days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
H. M. Piper and D. Garcia-Dorado
Cardiac protection takes off
Cardiovasc Res, July 15, 2009; 83(2): 163 - 164.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.