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Cardiovascular Research Advance Access [Accepted Manuscript] published online on February 27, 2009
Cardiovascular Research, doi:10.1093/cvr/cvp080
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Tetraspanins and Vascular Functions

Feng Zhang*, Jayaprakash Kotha*, Lisa K. Jennings§ and Xin A. Zhang§

Vascular Biology Center of Excellence, Center for Cancer Research, and Departments of Medicine and Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN, USA

§ To whom correspondence should be addressed: Vascular Biology Center of Excellence and Department of Medicine, H300 Coleman Building, 956 Court Avenue, Memphis, TN 38163, Tel: 901-448-3448 Fax: 901-448-7181 E-mail: xazhang{at}utmem.edu or ljennings{at}utmem.edu

Tetraspanins are multiple membrane-spanning proteins that likely function as the organizers of membrane microdomains. Tetraspanins associate with other membrane-bound molecules such as cell adhesion proteins, growth factor receptors, and Ig superfamily members and regulate key cellular processes such as adhesion, migration, and fusion. Tetraspanins are widely expressed in vascular and hematopoietic cells and are involved in both physiological as well as pathological processes related to angiogenesis, vascular injury, thrombosis, and hemostasis. A wide body of evidence suggests that tetraspanins directly regulate the development and functions of the vascular system and the pathogenesis of vascular diseases. This article reviews current understanding of the roles of tetraspanins in vascular functions.

Time for primary review: 18 Days

* These authors made equal contribution to this article.

Abbreviations: EC, endothelial cell(s); ECM, extracellular matrix; HUVEC, human umbilical vein endothelial cells; ICAM, intercellular adhesion molecule; KO, knock out; MMP, matrix metalloproteinase; PI-3K, phosphatidylinositol-3 kinase; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis; SMC, smooth muscle cells; TEM, tetraspanin-enriched microdomain; VCAM, vascular cell adhesion molecule; vWF, von Willebrand factor.


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