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Cardiovascular Research Advance Access [Accepted Manuscript] published online on January 29, 2009
Cardiovascular Research, doi:10.1093/cvr/cvp031
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Vascular NAD(P)H Oxidase Activation in Diabetes: A Double-Edged Sword in Redox Signaling

Ling Gao{dagger} and Giovanni E. Mann*

Cardiovascular Division, School of Medicine, King's College London, 150 Stamford Street, London SE1 9NH, U.K

* Correspondence to: Prof G.E. Mann, Cardiovascular Division, School of Medicine, Franklin-Wilkins Building (Rm 3.01), King's College London, 150 Stamford Street, London SE1 9NH, U.K., Tel. 0044-20-7848-4306, Fax 0044-20-7848-4500, Email giovanni.mann{at}kcl.ac.uk

Oxidative stress mediated by hyperglycemia-induced generation of reactive oxygen species (ROS) contributes significantly to the development and progression of diabetes and related vascular complications. NAD(P)H oxidase has been implicated as the major source of ROS generation in the vasculature in response to high glucose and advanced glycation end products. Sustained activation of NAD(P)H oxidase in diabetes may diminish intracellular levels of NADPH, an essential cofactor for endothelial NO synthase (eNOS) and several antioxidant systems. Recent evidence suggests that basal ROS production via NAD(P)H oxidase may upregulate antioxidant enzyme defenses via redox signaling. Thus, NAD(P)H oxidase may serve as a double-edged sword, with transient activation providing a feedback defense against excessive ROS generation through the activation of receptor tyrosine kinases and the redox-sensitive Nrf2-Keap1 signaling pathway. Overproduction of ROS leads to eNOS uncoupling, mitochondrial dysfunction and impaired antioxidant defenses due to depletion of intracellular NADPH. Given the largely negative outcome of antioxidant therapy in the treatment of diabetic complications, targeting the redox-sensitive transcription factor Nfr2 may provide an effective strategy to restore antioxidant defenses in diabetes.

KEYWORDS Diabetes; Endothelium; NAD(P)H oxidase; Mitochondria; eNOS; Redox signaling; Nrf2-Keap 1 signaling; Antioxidant defense genes

Time for primary review: 23 Days

{dagger} Present address: Division of Molecular Medicine, Cardiovascular Research Laboratories, Departments of Anesthesiology & Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA


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