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Cardiovascular Research Advance Access [Accepted Manuscript] published online on December 2, 2008
Cardiovascular Research, doi:10.1093/cvr/cvn333
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org.

MYOCARDIAL REPAIR/REMODELING FOLLOWING INFARCTION: ROLES OF LOCAL FACTORS

Yao Sun, MD, PhD

Division of Cardiovascular Diseases Department of Medicine University of Tennessee Health Science Center Memphis, Tennessee USA

Correspondence: Yao Sun, MD, Ph.D. Division of Cardiovascular Diseases Department of Medicine University of Tennessee Health Science Center 956 Court Ave, Box 20 Memphis, TN 38163 USA Tel: (901) 448-4921 Fax: (901) 448-4921 Email: yasun{at}utmem.edu

Heart failure is a global health problem, appearing most commonly in patients with previous myocardial infarction (MI). Cardiac remodeling, particularly fibrosis seen in both the infarcted and noninfarcted myocardium are recognized to be a major determinant of the development of impaired ventricular function, leading to a poor prognosis. Elucidating cellular and molecular mechanisms responsible for the accumulation of extracellular matrix is essential for designing cardioprotective and reparative strategies that could regress fibrosisafter infarction. Multiple factors contribute to left ventricular remodeling at different stages postMI. This review will discuss the role of oxidative stress and locally produced angiotensin (Ang)II in the pathogenesis of myocardial repair/remodeling after MI.

Time for primary review: 27 Days


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