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Cardiovascular Research Advance Access [Accepted Manuscript] published online on October 31, 2008
Cardiovascular Research, doi:10.1093/cvr/cvn292
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org.

Post-infarct remodelling: Contribution of wound healing and inflammation

Stefan Frantz, Johann Bauersachs and Georg Ertl

Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany

Address Correspondence to: Georg Ertl, M.D. Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg Josef-Schneider-Str. 2 97080 Würzburg Germany Phone +49-931-201-36301 Fax +49-931-201-36302 E-mail ertl_g{at}medizin.uni-wuerzburg.de

In human and experimental myocardial infarction cessation of blood supply leads to rapid necrosis of cardiac myocytes in the ischemic heart. Immediately after injury various intra- and inter-cellular pathways contribute to healing the myocardial wound in order to achieve tissue integrity and function. Myocardial infarction and the consequent loss of myocardium is the major aetiology for heart failure. Despite aggressive primary therapy, prognosis remains poor in patients with large infarction and severe left ventricular dysfunction. Thus, it would be highly desirable to improve healing of the cardiac wound to maintain structure and function of the heart. Healing in the heart occurs in overlapping phases. Herein, we review the inflammatory phase as a trigger of tissue formation.

KEYWORDS Myocardial infarction; healing; inflammation

Time for primary review: 24 Days


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