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Cardiovascular Research Advance Access first published online on June 6, 2008
This version [Corrected Proof] published online on June 30, 2008
Cardiovascular Research, doi:10.1093/cvr/cvn151
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination

Francesco Fazi1,2 and Clara Nervi1,2,*

1 Department of Histology and Medical Embryology, ‘Sapienza’ University of Rome, Italy
2 San Raffaele Bio-medical Park Foundation, Rome, Italy

* Corresponding author. Tel: +39 06 8031 9049/52; fax: +39 06 8031 9054. E-mail address: clara.nervi{at}uniroma1.it

Characterization of regulatory mechanisms affecting microRNA (miRNA) expression and activity is providing novel clues for the identification of genes and complex regulatory circuits that determine cell and tissue specificity. Here, we review the molecular events leading to miRNA biogenesis and activity, focusing above all on endogenous and epigenetic transcriptional networks involving miRNA in early development, cellular lineage specification/differentiation of nervous, skeletal and cardiac muscle tissues and in haematopoiesis, as the de-regulation of such networks may be relevant to disease pathogenesis.

KEYWORDS MicroRNAs; Transcription factors; Epigenetic gene regulation; Cell differentiation

Time for primary review: 37 days


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