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Cardiovascular Research Advance Access [Accepted Manuscript] published online on April 22, 2008
Cardiovascular Research, doi:10.1093/cvr/cvn098
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Spotlight issue on Signaling in Cardiac Metabolism: Transcriptional control of mitochondrial biogenesis. The central role of PGC-1{alpha}

Renée Ventura-Clapier, Anne Garnier and Vladimir Veksler

INSERM, U-769, F-92296 Châtenay-Malabry, France; Univ Paris-Sud, IFR141, F-92296 Châtenay-Malabry, France

Address for correspondence: Dr Renée Ventura-Clapier U-769 INSERM Faculté de Pharmacie, Université Paris-Sud5 rue J-B Clément 92296 Châtenay-Malabry France Tel: (33-1) 46.83.57.62. Fax: (33-1) 46.83.54.75. E-mail: renee.ventura{at}u-psud.fr

Although the concept of energy starvation in the failing heart was proposed decades ago, still very little is known about the origin of energetic failure. Recent advances in molecular biology have started to elucidate the transcriptional events governing mitochondrial biogenesis. In particular a great step forwards was taken with the discovery that peroxisome proliferator-activated receptor gamma co-activator (PGC-1{alpha}) is the master regulator of mitochondrial biogenesis. The molecular mechanisms underlying the downregulation of PGC-1{alpha} and the consequent decrease in mitochondrial function in heart failure are, however, still poorly understood. Indeed, the main pathways involved in mitochondrial biogenesis are thought to be up- rather than down-regulated in pathological hypertrophy and heart failure. The current review summarizes recent advances in this field and is restricted to the heart when cardiac data is available.

Time for primary review: 31 days


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