Skip Navigation



Cardiovascular Research Advance Access [Accepted Manuscript] published online on March 14, 2008
Cardiovascular Research, doi:10.1093/cvr/cvn074
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
79/2/269    most recent
cvn074v2
cvn074v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Chess, D. J.
Right arrow Articles by Stanley, W. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chess, D. J.
Right arrow Articles by Stanley, W. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Role of Diet and Fuel Overabundance in the Development and Progression of Heart Failure

David J. Chess1,2 and William C. Stanley1,2,

1 Department of Physiology and Biophysics School of Medicine, Case Western Reserve University, Cleveland, OH
2 Division of Cardiology,Department of Medicine University of Maryland, Baltimore, MD

Address for correspondence: William C. Stanley, Ph.D. Division of Cardiology, Department of Medicine University of Maryland-Baltimore 20 Penn St., HSF-II, Room S022 Baltimore, MD 21201, USA 410-706-3585 (Phone) 410-706-3583 (Fax) e-mail: wstanley{at}medicine.umaryland.edu

Under physiological conditions, the human heart derives energy from glucose, fatty acids and/or lactate depending upon substrate availability, circulating hormone levels, and nutritional status. Circulating free fatty acid and glucose levels often exceed the normal range, as observed with type 2 diabetes, obesity, or physical inactivity. Chronic exposure of the heart to high plasma levels of free fatty acids may cause accumulation of toxic lipid intermediates within cardiomyocytes. Furthermore, suppression of glucose oxidation by increased fatty acid uptake shunts glucose into the oxidative pentose phosphate and hexosamine biosynthetic pathways, both of which yield potentially harmful products. Noxious derivatives of aberrant glucose and fatty acid oxidation can activate signaling cascades leading to myocyte dysfunction or death, processes termed "glucotoxicity" and "lipotoxicity". This review discusses the effects of dietary extremes (e.g., high fat and high carbohydrate consumption) and substrate overabundance in the context of heart failure development and progression. Emerging data suggest that substrate excess leads to cardiac dysfunction and heart failure, which may be prevented or slowed by maintaining low body fat and high insulin sensitivity and consuming a diet of low glycemic load that is high in mono- and polyunsaturated fatty acids.

KEYWORDS Diet; Glucotoxicity; Heart; Lipotoxicity

Time for primary review: 24


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 HypertensionHome page
W. C. Stanley, K. B. Shah, and M. F. Essop
Does Junk Food Lead to Heart Failure?: Importance of Dietary Macronutrient Composition in Hypertension
Hypertension, December 1, 2009; 54(6): 1209 - 1210.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. Suzuki, M. Ueno, M. Uno, Y. Hirose, Y. Zenimaru, S. Takahashi, J.-i. Osuga, S. Ishibashi, M. Takahashi, M. Hirose, et al.
Effects of hormone-sensitive lipase disruption on cardiac energy metabolism in response to fasting and refeeding
Am J Physiol Endocrinol Metab, November 1, 2009; 297(5): E1115 - E1124.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. J. Chess, R. J. Khairallah, K. M. O'Shea, W. Xu, and W. C. Stanley
A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload
Am J Physiol Heart Circ Physiol, November 1, 2009; 297(5): H1585 - H1593.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
L. H. Opie and J. Knuuti
The adrenergic-Fatty Acid load in heart failure.
J. Am. Coll. Cardiol., October 27, 2009; 54(18): 1637 - 1646.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Serpillon, B. C. Floyd, R. S. Gupte, S. George, M. Kozicky, V. Neito, F. Recchia, W. Stanley, M. S. Wolin, and S. A. Gupte
Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH
Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H153 - H162.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
E. B. Levitan, A. Wolk, and M. A. Mittleman
Consistency With the DASH Diet and Incidence of Heart Failure
Arch Intern Med, May 11, 2009; 169(9): 851 - 857.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. A. Albert
Heart Failure in the Urban African Enclave of Soweto: A Case Study of Contemporary Epidemiological Transition in the Developing World
Circulation, December 2, 2008; 118(23): 2323 - 2325.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. J. Chess, W. Xu, R. Khairallah, K. M. O'Shea, W. J. Kop, A. M. Azimzadeh, and W. C. Stanley
The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet
Am J Physiol Heart Circ Physiol, December 1, 2008; 295(6): H2223 - H2230.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. J. Chicco, G. C. Sparagna, S. A. McCune, C. A. Johnson, R. C. Murphy, D. A. Bolden, M. L. Rees, R. T. Gardner, and R. L. Moore
Linoleate-Rich High-Fat Diet Decreases Mortality in Hypertensive Heart Failure Rats Compared With Lard and Low-Fat Diets
Hypertension, September 1, 2008; 52(3): 549 - 555.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
G. D. Lopaschuk and D. P. Kelly
Signalling in cardiac metabolism
Cardiovasc Res, July 15, 2008; 79(2): 205 - 207.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.