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Cardiovascular Research Advance Access [Accepted Manuscript] published online on March 7, 2008
Cardiovascular Research, doi:10.1093/cvr/cvn061
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

GENOMICS IN CARDIAC METABOLISM

Jane-Lise Samuela,b, Marcus C. Schaubc, Michael Zauggd, Mamas Mamase, Warwick B. Dunnf and Bernard Swynghedauwa,b,

a U689 INSERM,, 41 Bd de la Chapelle. Paris, France
b Université Denis Diderot, Paris 7, Paris, France
c Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
d Institute of Anaesthesiology, University Hospital Zurich, Zurich, Switzerland
e Department of Cardiology, Manchester Royal Infirmary. Manchester, UK
f The Manchester Centre for Integrative Systems Biology, University of Manchester, UK

Correspondance to: Dr. Bernard Swynghedauw: U689 INSERM. Hôpital Lariboisière, 41 Bd de la Chapelle, 75475 Paris Cedex 10. France. Tel: 33 6 86 28 33 86, Fax 33153216739 Bernard.Swynghedauw{at}larib.inserm.fr

Cell biology is in transition from reductionism to a more integrated science. Large-scale analysis of genome structure, gene expression and metabolites are new technologies available for studying cardiac metabolism in diseases known to modify cardiac function. These technologies have several limitations and this review aims both to assess and take a critical look at some important results obtained in genomics restricted to molecular genetics, transcriptomics and metabolomics of cardiac metabolism in pathophysiological processes known to alter myocardial function. Therefore our goal was to delineate new signalling pathways and new areas of research from the vast amount of data already published on genomics as applied to cardiac metabolism in diseases such as coronary heart disease (CHD), heart failure (HF) and ischemic reperfusion.

KEYWORDS Cardiac metabolism; Genome-wide analysis; Metabolomics; Transcriptomics

Time for primary review: 15 days

Note. Gene nomenclature can be found on http://www.genecards.org/


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