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Cardiovascular Research Advance Access [Accepted Manuscript] published online on February 19, 2008
Cardiovascular Research, doi:10.1093/cvr/cvn045
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

BESIDES THE ADHESION: NEW PERSPECTIVES OF INTEGRIN FUNCTIONS IN ANGIOGENESIS

Guido Serini, Lucia Napione, Marco Arese and Federico Bussolino

Department of Oncological Sciences
Institute for Cancer Research and Treatment
University of Torino
10060 Candiolo- ITALY

Corresponding author: Federico Bussolino, M.D., PhD., Department of Oncological Sciences, Sp 142, Km 3.05, 10060 Candiolo- Italy Phone: +390119933347 Fax: +390119933524 email: federico.bussolino{at}unito.it

During angiogenic remodeling in embryo and adult life, endothelial cells lining blood vessel walls dynamically modify their integrin-mediated adhesive contacts with the surrounding extracellular matrix. However, besides regulating cell adhesion and migration, integrins dynamically participate in a network with soluble molecules and their receptors. Angiogenesis is characterized by opposing autocrine and paracrine loops of growth factors and semaphorins that regulate the activation of integrins on the endothelial surface through tyrosine kinase receptors and the neuropilin/plexin system. Moreover, pro- and anti-angiogenic factors can directly bind integrins and regulate endothelial cell behavior. This review summarizes the recent progress in understanding the reciprocal interactions between integrins, tyrosine kinase receptors and semaphorin receptors.

Time for primary review: 11 days


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