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Cardiovascular Research Advance Access [Accepted Manuscript] published online on August 23, 2007
Cardiovascular Research, doi:10.1093/cvr/cvm007
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Angiogenesis and obesity

H.R. Lijnen

Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium

Address for correspondence: H.R. Lijnen, Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O & N 1, Herestraat 49, Box 911, 3000 Leuven, Belgium, Tel 32-16-345771, Fax 32-16-345990, e-mail: roger.lijnen{at}med.kuleuven.be

Development of obesity is associated with substantial modulation of adipose tissue structure, involving adipogenesis, angiogenesis and extracellular matrix remodeling. These processes require proteolytic activity, provided mainly by the fibrinolytic (plasminogen/plasmin), matrix metalloproteinase and ADAM/ADAMTS systems. In early stage development of adipose tissue, adipogenesis is tightly associated with angiogenesis. Thus, adipose tissue explants trigger blood vessel formation, and in turn adipose tissue endothelial cells (ECs) promote preadipocyte differentiation. Modulation of angiogenesis and of proteolytic systems may have the potential to impair adipose tissue development.

KEYWORDS angiogenesis; vascular remodeling; obesity

Time for primary review: 23 days


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