Skip Navigation


Cardiovascular Research Advance Access originally published online on June 5, 2009
Cardiovascular Research 2009 83(3):425-435; doi:10.1093/cvr/cvp165
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
83/3/425    most recent
cvp165v2
cvp165v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sipido, K. R.
Right arrow Articles by Dambrauskaite, V.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sipido, K. R.
Right arrow Articles by Dambrauskaite, V.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Identifying needs and opportunities for advancing translational research in cardiovascular disease{dagger}

Karin R. Sipido1,*, Alain Tedgui2, Steen D. Kristensen3, Gerard Pasterkamp4, Heribert Schunkert5, Martin Wehling6, Philippe G. Steg7, Wolfgang Eisert8, Frank Rademakers9, Barbara Casadei10, Valentin Fuster11, Elisabetta Cerbai12, Gerd Hasenfuss13, Francisco Fernandez-Aviles14, David Garcia-Dorado15, Maria Vidal16, Manuel Hallen16 and Virginija Dambrauskaite16

1 Experimental Cardiology, University of Leuven, KUL Campus Gasthuisberg O/N 7th floor, Herestraat 49, B-3000 Leuven, Belgium
2 INSERM U689, Hôpital Lariboisière, Paris, France
3 Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
4 Experimental Cardiology Laboratory, Utrecht Medical Center, Utrecht, The Netherlands
5 Medizinische Klinik II, Lübeck University, Lübeck, Germany
6 Clinical Pharmacology Mannheim, University of Heidelberg, Mannheim, Germany
7 Department of Cardiology, Hôpital Bichat-Claude Bernard, Paris, France
8 Boehringer Ingelheim, University of Hannover, Hannover, Germany
9 Cardiac Imaging, University of Leuven, Leuven, Belgium
10 Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
11 Mount Sinai School of Medicine, Mount Sinai Hospital, New York, NY, USA
12 Center of Molecular Medicine, University of Florence, Firenze, Italy
13 Department of Cardiology and Pneumology, Georg-August-University, Göttingen, Germany
14 Department of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
15 Hospital Universitari Vall d’Hebron, Barcelona, Spain
16 DG Research, Directorate Health, EC, Brussels, Belgium

* Corresponding author. Tel: +32 16 347153; fax: +32 16 345844. E-mail address: karin.sipido@med.kuleuven.be

The first 150 words of the full text of this article appear below.


   1. The success of cardiovascular research: two sides of a story
 
In Western Europe, as in the USA, mortality of cardiovascular disease (CVD) has declined significantly in the last 30 years. Life expectancy for patients with coronary heart disease in the USA increased on average by 3 years between 1970 and 2000.1 Several epidemiological analyses support this positive evolution. An analysis of the underlying causes identifies improvements in quality of care and treatment as a major cause, accounting from 50 up to 75% of the success depending on the study samples, the remainder being accounted for by changes in lifestyle and prevention.2 Research and development in several areas of CVD have contributed to this success. In acute coronary events, the identification and development of efficient and safe thrombolytic agents followed by percutaneous coronary intervention with stent implantation were milestones in the reduction of acute mortality and salvage of myocardium.3–5 Statins have brought a major advance in preventing the progression of atherosclerotic . . . [Full Text of this Article]


   2. The framework of translational research
 

   3. The case of clinical research through randomized trials
 

   4. The need for a long-term view
 

   5. Needs and opportunities in cardiovascular research
 
5.1 Atherosclerotic disease
5.1.1 New concepts for translation
5.1.2 Thrombosis research
5.1.3 Generating new hypotheses from large-scale (post)-genomic studies
5.2 Cardiovascular imaging
5.3 Arrhythmias
5.4 Heart failure
5.5 New potential for stem cells
5.6 New potential for cardiac protection in ischaemia

   6. General conclusions
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?