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Cardiovascular Research Advance Access originally published online on December 18, 2008
Cardiovascular Research 2009 81(3):409-411; doi:10.1093/cvr/cvn352
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

A translational approach to myocardial remodelling

Javier Díez1,2,* and Georg Ertl3

1 Division of Cardiovascular Sciences, Centre of Applied Medical Research, University of Navarra, School of Medicine, Avda. Pío XII 55, 31008 Pamplona, Spain
2 Department of Cardiology and Cardiovascular Surgery, University Clinic, University of Navarra, Avda. Pío XII 55, 31008 Pamplona, Spain
3 Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Würzburg, Germany

* Corresponding author. Tel: +34 948 194700; fax: +34 948 194716. E-mail address: jadimar@unav.es

The first 10% of the full text of this article appears below.

The concept of cardiac remodelling was initially created to describe the changes in the anatomy of the left ventricle that occur following myocardial infarction.1 Today myocardial remodelling is used to qualify a variety of changes in the biophysiology of the cardiomyocyte, the volume and composition of cardiomyocyte, and non-cardiomyocyte compartments, and the geometry and architecture of the left ventricular chamber that occur in response to myocardial infarction, pressure or volume overload, cardiomyopathic states, and exposure to infectious or cardiotoxic agents.2

Myocardial remodelling results from modifications that are not necessarily adaptive to the initial insult, but pathological and potentially self-perpetuating in a progressive vicious circle. In addition, the effects of the insult on the final phenotype are modulated by several interfering factors, including senescence, obesity, diabetes, a number of cardiac and systemic humoral factors and, probably, genetics.3 Myocardial remodelling may result in alterations . . . [Full Text of this Article]


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