Skip Navigation


Cardiovascular Research Advance Access originally published online on May 16, 2008
Cardiovascular Research 2008 79(3):360-376; doi:10.1093/cvr/cvn120
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
79/3/360    most recent
cvn120v2
cvn120v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kleemann, R.
Right arrow Articles by Kooistra, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kleemann, R.
Right arrow Articles by Kooistra, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org.

Cytokines and atherosclerosis: a comprehensive review of studies in mice

Robert Kleemann*, Susanne Zadelaar and Teake Kooistra

TNO-BioSciences, Gaubius-Laboratory, Department of Vascular and Metabolic Diseases, PO Box 2215, 2301 CE Leiden, The Netherlands

* Corresponding author. Tel: +31 71 518 1467; fax: +31 71 518 1901. E-mail address: robert.kleemann{at}tno.nl

In the past few years, inflammation has emerged as a major driving force of atherosclerotic lesion development. It is now well-established that from early lesion to vulnerable plaque formation, numerous cellular and molecular inflammatory components participate in the disease process. The most prominent cells that invade in evolving lesions are monocyte-derived macrophages and T-lymphocytes. Both cell types produce a wide array of soluble inflammatory mediators (cytokines, chemokines) which are critically important in the initiation and perpetuation of the disease. This review summarizes the currently available information from mouse studies on the contribution of a specified group of cytokines expressed in atherosclerotic lesions, viz. interleukins (IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-10, IL-12, IL-18, IL-20) and macrophage-associated cytokines [tumour necrosis factor-{alpha} (TNF-{alpha}); macrophage migration inhibitory factor (MIF); interferon-{gamma} (IFN-{gamma}); colony stimulating factors G-CSF,-M-CSF,-GM-CSF) to atherogenesis. Emphasis is put on the consistency of the effects of these cytokines, i.e. inasmuch an effect depends on the experimental approach applied (overexpression/deletion, strain, gender, dietary conditions, and disease stage). An important outcome of this survey is (i) that only for a few cytokines there is sufficient consistent data allowing classifying them as typically proatherogenic (IL-1, IL-12, IL-18, MIF, IFN-{gamma}, TNF-{alpha}, and M-CSF) or antiatherogenic (IL-10) and (ii) that some cytokines (IL-4, IL-6 and GM-CSF) can exert pro- or anti-atherogenic effects depending on the experimental conditions. This knowledge can be used for improved early detection, prevention and treatment of atherosclerosis.

KEYWORDS Atherosclerosis; Inflammation; Cytokines; Interleukins; Macrophage

Time for primary review: 19 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Circ. Res.Home page
L. Verschuren, T. Kooistra, J. Bernhagen, P. J. Voshol, D. M. Ouwens, M. van Erk, J. de Vries-van der Weij, L. Leng, J. H. van Bockel, K. W. van Dijk, et al.
MIF Deficiency Reduces Chronic Inflammation in White Adipose Tissue and Impairs the Development of Insulin Resistance, Glucose Intolerance, and Associated Atherosclerotic Disease
Circ. Res., July 2, 2009; 105(1): 99 - 107.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Goyette, W. X. Yan, E. Yamen, Y. M. Chung, S. Y. Lim, K. Hsu, F. Rahimi, N. Di Girolamo, C. Song, W. Jessup, et al.
Pleiotropic Roles of S100A12 in Coronary Atherosclerotic Plaque Formation and Rupture
J. Immunol., July 1, 2009; 183(1): 593 - 603.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. R. Thompson, A. M. Mazurkiewicz-Munoz, J. Suttles, C. Carter-Su, and D. A. Bernlohr
Interaction of Adipocyte Fatty Acid-binding Protein (AFABP) and JAK2: AFABP/aP2 AS A REGULATOR OF JAK2 SIGNALING
J. Biol. Chem., May 15, 2009; 284(20): 13473 - 13480.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. Chen, A. Frister, S. Wang, A. Ludwig, H. Behr, S. Pippig, B. Li, A. Simm, B. Hofmann, C. Pilowski, et al.
Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production
Am J Physiol Heart Circ Physiol, April 1, 2009; 296(4): H987 - H996.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
V. Samokhvalov, P. J. Bilan, J. D. Schertzer, C. N. Antonescu, and A. Klip
Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells
Am J Physiol Endocrinol Metab, January 1, 2009; 296(1): E37 - E46.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
F. Montecucco and F. Mach
Common inflammatory mediators orchestrate pathophysiological processes in rheumatoid arthritis and atherosclerosis
Rheumatology, January 1, 2009; 48(1): 11 - 22.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.