Cardiovascular Research Advance Access originally published online on March 18, 2008
Cardiovascular Research 2008 78(3):413-421; doi:10.1093/cvr/cvn081
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vascular repair by endothelial progenitor cells
Cardiovascular Division, King's College London, 125 Cold harbour Lane, London SE5 9NU, UK
* Corresponding author. Tel: +44 20 7848 5322; fax: +44 20 7848 5296. E-mail address: qingbo.xu{at}kcl.ac.uk
Accumulating evidence indicates the impact of endothelial progenitor cells (EPCs) in vascular repair. In patients, the number of EPCs is negatively correlated with the severity of atherosclerosis. In various animal models, transplantation of bone marrow-derived progenitor cells could sufficiently rescue organ function and enhance vascular repair and tissue regeneration. Increase in the number of circulating progenitors, induced by cell transfusion or enhanced mobilization, can also enhance restoration and integrity of the endothelial lining, suppress neointimal formation, and increase blood flow to ischaemic sites. However, the beneficial outcome of EPC infusion very much depends on the growth and differentiation factors within the tissue, cell-to-cell interactions, and the degree of injury. As highlighted by several studies, EPCs derive from different sources including bone marrow and non-bone marrow organs such as the spleen, the functional repair properties of which may vary with the maturation state of the cell. Thus, understanding the molecular mechanisms involved in EPC-repairing processes is essential. In the present review we focus on the role of EPCs in vascular diseases, and we provide an update on the mechanisms of EPC mobilization, homing, and differentiation.
KEYWORDS Endothelial progenitor cells; Vascular diseases; Atherosclerosis; Vascular repair
Time for primary review: 21 days
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Song, X. Yu, X. Cui, G. Zhu, G. Zhao, J. Chen, and L. Huang Blockade of Connexin 43 Hemichannels Reduces Neointima Formation After Vascular Injury by Inhibiting Proliferation and Phenotypic Modulation of Smooth Muscle Cells Experimental Biology and Medicine, October 1, 2009; 234(10): 1192 - 1200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zavada, L. Kideryova, R. Pytlik, Z. Hruskova, and V. Tesar Reduced number of endothelial progenitor cells is predictive of early relapse in anti-neutrophil cytoplasmic antibody-associated vasculitis Rheumatology, October 1, 2009; 48(10): 1197 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Hibbert, X. Ma, A. Pourdjabbar, E. Holm, K. Rayner, Y.-X. Chen, J. Sun, L. Filion, and E. R. O'Brien Inhibition of endothelial progenitor cell glycogen synthase kinase-3{beta} results in attenuated neointima formation and enhanced re-endothelialization after arterial injury Cardiovasc Res, July 1, 2009; 83(1): 16 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Moreno, J. Sanz, and V. Fuster Promoting Mechanisms of Vascular Health: Circulating Progenitor Cells, Angiogenesis, and Reverse Cholesterol Transport J. Am. Coll. Cardiol., June 23, 2009; 53(25): 2315 - 2323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Yao, A. L. Firth, R. S. Sacks, A. Ogawa, W. R. Auger, P. F. Fedullo, M. M. Madani, G. Y. Lin, N. Sakakibara, P. A. Thistlethwaite, et al. Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension Am J Physiol Lung Cell Mol Physiol, June 1, 2009; 296(6): L870 - L878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Di Stefano, C. Cencioni, G. Zaccagnini, A. Magenta, M. C. Capogrossi, and F. Martelli p66ShcA modulates oxidative stress and survival of endothelial progenitor cells in response to high glucose Cardiovasc Res, June 1, 2009; 82(3): 421 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H E Thomas, P J Avery, J M Ahmed, R Edwards, I Purcell, A G Zaman, H M Arthur, and B D Keavney Local vessel injury following percutaneous coronary intervention does not promote early mobilisation of endothelial progenitor cells in the absence of myocardial necrosis Heart, April 1, 2009; 95(7): 555 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Cummins A new addition to the renin-angiotensin peptide family: proAngiotensin-12 (PA12) Cardiovasc Res, April 1, 2009; 82(1): 7 - 8. [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Sussman Showing up Isn't Enough for Vascularization: Persistence Is Essential Circ. Res., November 21, 2008; 103(11): 1200 - 1201. [Full Text] [PDF]
|
|
|
|
 |
|
 B. D. Lamon and D. P. Hajjar Inflammation at the Molecular Interface of Atherogenesis: An Anthropological Journey Am. J. Pathol., November 1, 2008; 173(5): 1253 - 1264. [Abstract] [Full Text] [PDF]
|
|