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Cardiovascular Research Advance Access originally published online on August 23, 2007
Cardiovascular Research 2008 78(2):286-293; doi:10.1093/cvr/cvm007
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Angiogenesis and obesity

H. Roger Lijnen*

Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O & N 1, Herestraat 49, Box 911, 3000 Leuven, Belgium

* Corresponding author. Tel: +32 16 345771; fax: +32 16 345990. E-mail address: roger.lijnen{at}med.kuleuven.be

Development of obesity is associated with substantial modulation of adipose tissue structure, involving adipogenesis, angiogenesis, and extracellular matrix remodelling. These processes require proteolytic activity, provided mainly by the fibrinolytic (plasminogen/plasmin), matrix metalloproteinase, and ADAM/ADAMTS systems. In early-stage development of adipose tissue, adipogenesis is tightly associated with angiogenesis. Thus, adipose tissue explants trigger blood vessel formation, and in turn adipose tissue endothelial cells promote pre-adipocyte differentiation. Modulation of angiogenesis and of proteolytic systems may have the potential to impair adipose tissue development.

KEYWORDS Angiogenesis; Vascular remodelling; Obesity

Time for primary review: 23 days


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