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Cardiovascular Research Advance Access originally published online on January 10, 2008
Cardiovascular Research 2008 77(4):616-618; doi:10.1093/cvr/cvn004
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function

R. John Solaro* and Pieter P. de Tombe

Department of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, College of Medicine, 835 S. Wolcott Avenue, Chicago, IL 60612, USA

* Corresponding author. Tel: +1 312 996 7620; fax: +1 312 996 1414. E-mail address: solarorj@uic.edu

See reviews in this series by Davis and Tikunova,1 Hanft et al.,2 Linke,5 Hamdani et al.,6 Morimoto,10 and Boateng and Goldspink.13 Original articles in the series are by Iorga et al.,8 Revera et al.,9 Gopal et al.,12 Burgoyne et al.14

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Review and original articles in this focused issue of the Journal highlight the increased understanding of the role of sarcomeric proteins in control of cardiac function downstream of Ca2+ signalling. Figure 1 provides a context for integrating these articles in a minimal model of sarcomeric function in long- and short-term responses of the heart to stressors. In the model, state changes in the form of a physiological extrinsic stress, such as exercise or a pathophysiological stress such as hypertension promote a stream of mechanical and chemical signals, indicated as cytoskeletal, neurohormonal, and redox strains. Cytoskeletal strain induced by sarcomere length changes engage the Frank–Starling mechanism and also induce neurohormonal strains, as do feedback mechanisms. Readout of these neurohormonal signals is altered protein phosphorylation of cellular proteins including membrane proteins, transcription factors, and the sarcomeric proteins. Altered redox . . . [Full Text of this Article]


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Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function
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Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function
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