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Cardiovascular Research Advance Access originally published online on January 14, 2008
Cardiovascular Research 2008 77(4):609-611; doi:10.1093/cvr/cvn009
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

When the heart sleeps... Is the vagus resetting the myocardial ‘redox clock’?

Cecilia Vecoli1 and Nazareno Paolocci1,2,*

1 Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 835 Ross Building, Johns Hopkins Hospital, 720 Rutland Avenue, Baltimore, MD 21205, USA
2 Section of General Pathology, Department of Clinical Medicine, University of Perugia, Perugia, Italy

* Corresponding author. Tel: +1 410 502 6165; fax: +1 410 502 2558. E-mail address: npaoloc1@jhmi.edu

Editorial commentary on ‘Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction’ (Takaki Tsutsumi et al., pp. 713–721.)

The first 10% of the full text of this article appears below.

"...living in the very copper rigging and secular miracle of communication

untroubled by the dumb voltages flickering their miles, the night long

in the thousands of unheard messages".

Thomas Pynchon, from The Crying of Lot 49 (1966)

Reactive oxygen species (ROS) are main actors in the evolving drama of congestive heart failure (CHF),1 a neuroendocrine disorder in which excess ROS signalling contributes to sympathetic efferent fibre hyperactivation.2 Enhanced sympathetic outflow favours arrhythmias, myocardial remodelling/dysfunction and premature death (Figure 1), thus having pathogenetic and prognostic meaning. However, the sympathetic ‘arm’ of the autonomic nervous system (ANS) acts not only as a ‘victim’ of ROS but also as an ‘executioner’ of further ROS-induced myocardial damage. Indeed, spill-over of catecholamines and other hypertrophic agents . . . [Full Text of this Article]


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Related articles in Cardiovasc Res:

Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction
Takaki Tsutsumi, Tomomi Ide, Mayumi Yamato, Wataru Kudou, Makoto Andou, Yoshitaka Hirooka, Hideo Utsumi, Hiroyuki Tsutsui, and Kenji Sunagawa
Cardiovasc Res 2008 77: 713-721. [Abstract] [Full Text]  

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Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction
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