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Cardiovascular Research Advance Access originally published online on November 11, 2007
Cardiovascular Research 2008 77(2):234-236; doi:10.1093/cvr/cvm066
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Sarcoplasmic reticulum–mitochondrial interaction in the mechanism of acute reperfusion injury

Hans Michael Piper*, Yaser Abdallah, Sascha Kasseckert and Klaus-Dieter Schlüter

Institute of Physiology, Justus Liebig University, Aulweg 129, 35392 Giessen, Germany

* Corresponding author. Tel: +49 641 99 47 241; fax: +49 641 99 47 239. E-mail address: michael.piper@physiologie.med.uni-giessen.de

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Currently, restoring blood flow in an acutely occluded vessel represents the most effective, long-term clinical therapy for acute myocardial infarction. Experimental research over the past years has demonstrated that the first minutes of reperfusion represent a window of opportunity for additional therapy that is yet unused in the clinical setting. Experimentally, it has been shown that a considerable part of myocardial injury developing after an episode of prolonged ischaemia and subsequent reperfusion is due to causes emerging during the period of reperfusion.1–6 This type of injury has been termed ‘reperfusion injury’. For a long time it had been difficult to prove the existence of this type of injury; this could only be done by identifying interventions applied just at the time of reperfusion that would reduce the otherwise resulting myocardial injury. Early studies in this area had shown that interventions during . . . [Full Text of this Article]


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