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Cardiovascular Research Advance Access originally published online on November 13, 2007
Cardiovascular Research 2008 77(2):231-233; doi:10.1093/cvr/cvm070
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Sarcoplasmic reticulum and mitochondria in cardiac pathophysiology

David Garcia-Dorado1,*, Hans Michael Piper2 and David A. Eisner3

1 Servicio de Cardiología, Institut de Recerca, Hospital Vall d'Hebron, Pg. Vall d'Hebron 119-129, 08035 Barcelona, Spain
2 Insitute of Physiology, Justus Liebig University of Giessen, Giessen, Germany
3 Unit of Cardiac Physiology, University of Manchester, Manchester, UK

* Corresponding author. Tel: +34 93 489 4038; fax: +34 93 489 4032. E-mail address: dgdorado@ir.vhebron.net

The first 10% of the full text of this article appears below.


   1. Introduction
 
Muscle cells, and in particular cardiomyocytes, consume a large amount of chemical energy to produce mechanical work. Myofilament contraction is regulated and synchronized within the cell by rapid, transient changes in the cytosolic Ca2+ concentration. Most of this calcium is released from the sarcoplasmic reticulum (SR), which has a large surface for Ca2+ transport, in close contact with the myofilaments. In between the myofilaments, cardiomyocytes are packed with mitochondria. These generate the energy needed for myofilament contraction, but serve also as an additional store for Ca2+. Thus, SR and mitochondria interact physiologically to control cellular Ca2+ homeostasis. It is partly through the Ca2+ loading of the mitochondria that their energy production is matched with the contractile energy demand.

Mitochondria are now recognized as an essential effector structure determining cell death and survival. This is not only . . . [Full Text of this Article]


   2. Recent advances in sarcoplasmic reticulum physiology
 

   3. The role of the SR in arrhythmia, hypertrophy, and heart failure
 

   4. Recent news on mitochondria
 

   5. Sarcoplasmic-reticulum–mitochondrial interactions
 

   6. Summary
 

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