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Cardiovascular Research Advance Access originally published online on November 11, 2007
Cardiovascular Research 2008 77(1):6-7; doi:10.1093/cvr/cvm065
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Journeying down the long and winding road: the whole picture of volume-activated Cl– channel activation in cardiac myocytes

Sung Joon Kim and Yung E. Earm*

Department of Physiology, Seoul National University College of Medicine, 28 Yonkeun-Dong, Chongno-ku, Seoul 110-799, Korea

* Corresponding author. Tel: +82 2 740 8224; fax: +82 2 763 9667. E-mail address: earmye@snu.ac.kr

The first 10% of the full text of this article appears below.

Patch-clamp studies of anion channels show a bewildering variety in their properties and regulation mechanisms.2 Amongst them, the anion channels activated by hypo-osmotic cell swelling (ICl,swell) have drawn attention because of their wide expression in virtually every vertebrate cell(s), including cardiac myocytes, and their critical roles in cell volume regulation.2–4 Cells need to regulate their volume in the face of several external and internal challenges. For this purpose, cells are endowed with various ion channels and transporters that become activated upon cell swelling or shrinkage. ICl,swell are also called by different names like volume-regulated . . . [Full Text of this Article]


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