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Cardiovascular Research 2007 76(2):202-203; doi:10.1016/j.cardiores.2007.08.012
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Copyright © 2007, European Society of Cardiology

Drug-induced torsades de pointes — A form of mechano-electric feedback?

Larissa Fabritz*

Department of Cardiology and Angiology and Centre for Interdisciplinary Clinical Research (IZKF), University Hospital Münster, 48129 Münster, Germany

*Tel.: +49 251 83 46034; fax: +49 251 83 47864. fabritzl@uni-muenster.de

Received 22 August 2007; accepted 24 August 2007

The first 10% of the full text of this article appears below.

See article by Gallacher et al. [1] (pages 247–256) in this issue.

In this issue of Cardiovascular Research, Gallacher et al. report findings on a novel canine model of drug-induced long-QT syndrome [1]. In this model, torsades de pointes (TdP) arrhythmia was induced in anaesthetised dogs by bolus injections of the β-adrenoreceptor agonist isoproterenol during selective inhibition of the slow component of the delayed-rectifier potassium current IKs by HMR1556. Isoproterenol induced TdP in 94% of dogs tested. Authors examined the interaction of putative mechanisms of induction of TdP. Blockade of IKs mimics the functional effects of . . . [Full Text of this Article]


   1. Excitation–contraction coupling or mechano-electric feedback?
 

   2. The trigger matters
 

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