Skip Navigation

Cardiovascular Research 2007 75(3):455-456; doi:10.1016/j.cardiores.2007.06.009
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Schulze-Bahr, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schulze-Bahr, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2007, European Society of Cardiology

Cardiac sodium channels: Dysregulation meets myocardial failure

Eric Schulze-Bahr1,*

Department of Cardiology and Angiology, University Hospital Münster, the Leibniz-Institute for Arteriosclerosis Research (LIFA) at the University of Münster, the Centre for Interdisciplinary Clinical Research (IZKF) of the University Hospital Münster, Germany

* Tel.: +49 251 83 529 82; fax: +49 251 83 575 70. Eric.Schulze-Bahr@ukmuenster.de http://www.medc.uni-muenster.de

Received 3 June 2007; accepted 15 June 2007

The first 10% of the full text of this article appears below.

See article by Hesse et al. [12] (pages 498–509) in this issue.

Within the orchestra of cardiac ion channels, voltage–gated Na+ channels have a key function in the determination of the amplitude and slope of the action potential upstroke. Both are important in the control of impulse conduction velocity and maintenance of appropriate waves of excitation through the working myocardium. The main ({alpha}-) subunit of the cardiac sodium channel is encoded by the SCN5A (Nav1.5) gene, and the INa current mediated is responsible for the membrane depolarization. Fast inactivation of sodium . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Circ Arrhythmia ElectrophysiolHome page
J. Ge, A. Sun, V. Paajanen, S. Wang, C. Su, Z. Yang, Y. Li, S. Wang, J. Jia, K. Wang, et al.
Molecular and Clinical Characterization of a Novel SCN5A Mutation Associated With Atrioventricular Block and Dilated Cardiomyopathy
Circ Arrhythmia Electrophysiol, June 1, 2008; 1(2): 83 - 92.
[Abstract] [Full Text] [PDF]