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Cardiovascular Research 2007 75(1):5-6; doi:10.1016/j.cardiores.2007.05.011
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Copyright © 2007, European Society of Cardiology

Understanding the cardiac role of K2P channels: A new TASK for electrophysiologists

Flavien Charpentier*

Inserm, U533, Nantes, F-44000, France
Université de Nantes, Faculté de médecine, Nantes, F-44000, France
CHU de Nantes, l'institut du thorax, Nantes, F-44000, France

* INSERM U533, l'Institut du Thorax, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes cedex, France. Tel.: +33 240 41 28 44; fax: +33 240 41 29 50. flavien.charpentier@nantes.inserm.fr

Received 4 May 2007; accepted 8 May 2007

The first 10% of the full text of this article appears below.

See article by Putzke et al. [6] (pages 59–68) in this issue.

Two-pore-domain K+ channels (K2P channels) form a newly identified class of 15 K+ channels that possess four transmembrane-spanning domains and two pore domains. Studies in heterologous systems suggest that functional K2P channels are dimers with an overall topology close to that of inward rectifier channels. Heterologous expression of these channels gives rise to instantaneous, non-inactivating K+ currents that display little or no voltage dependence, suggesting that they might contribute to background . . . [Full Text of this Article]


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