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Cardiovascular Research 2007 74(3):339-340; doi:10.1016/j.cardiores.2007.03.026
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Copyright © 2007, European Society of Cardiology

Apelin and vascular dysfunction in type 2 diabetes

Olaf Grisk*

Department of Physiology, University of Greifswald, Greifswalder Str. 11c, D17495 Karlsburg, Germany

* Tel.: +49 3834 8619300; fax: +49 3834 8618310. Email address: grisko@uni-greifswald.de

Received 21 March 2007; accepted 30 March 2007

The first 10% of the full text of this article appears below.

See article by Zhong et al. [13] (pages 388–395) in this issue.

The apelin receptor APJ belongs to the family of seven-transmembrane domain receptors and is coupled to inhibitory G-proteins [1,2]. Apelin is synthesized as a 77 amino acid pre-pro-peptide that can be cleaved into fragments of different sizes that activate APJ [1,2]. Apelin peptides have been shown to affect many biological functions in mammals including the neuroendocrine, cardiovascular, and immune systems [1]. It can act via autocrine, paracrine, endocrine, and exocrine signalling [1].

In the cardiovascular system apelin has been shown to increase cardiac contractility when administered in pharmacological doses . . . [Full Text of this Article]


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