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Cardiovascular Research 2007 74(1):6-7; doi:10.1016/j.cardiores.2007.02.003
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Copyright © 2007, European Society of Cardiology

Taking ion channel degradation to heart

Joachim R. Ehrlich*

Division of Cardiology, Section of Electrophysiology, J.W. Goethe-University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany

* Tel.: +49 (69) 6301 83661; fax: +49 (69) 6301 4387. Email address: j.ehrlich@em.uni-frankfurt.de

Received 30 January 2007; accepted 5 February 2007

The first 10% of the full text of this article appears below.

See article by Jespersen et al. [5] (pages 64–74) in this issue.

A balance between synthesis and degradation of cellular proteins is of natural importance to regulation of protein levels and necessary to retain viability of living cells. Protein degradation often occurs via targeting through ubiquitination and subsequent decomposition in the cellular proteasome [1]. Some other pathways may either not utilize ubiquitination or degrade proteins via lysosomal catalysis. Ligation of proteins to ubiquitin (a small reusable 8.5-kDa protein) requires a sequential . . . [Full Text of this Article]


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