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Cardiovascular Research 2007 73(3):450-452; doi:10.1016/j.cardiores.2006.12.004
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Copyright © 2006, European Society of Cardiology

Macrovascular disease in type 2 diabetes: We do need animal models for in vivo studies

Alain Nitenberg*

AP-HP, Centre Hospitalier Universitaire Jean Verdier, Service de Physiologie et d'Explorations Fonctionnelles, Bondy, France, and Université Paris XIII, UFR Léonard de Vinci, Bobigny, France

* Service de Physiologie et d'Explorations Fonctionnelles, Hôpital Jean Verdier, Avenue du 14 Juillet, 93140 Bondy, France. Tel.: +33 1 48 02 65 50; fax: +33 1 48 02 65 67. Email address: alain.nitenberg@jvr.aphp.fr

Received 22 November 2006; accepted 5 December 2006

The first 10% of the full text of this article appears below.

See article by Bouvet et al. [6] (pages 504–511) in this issue.

Type 2 diabetes and its complications has become a major public health problem in Western countries. The number of diabetic patients in the world is estimated to be about 200 million, and prevalence of type 2 diabetes will increase not only in the West due to overweight and obesity epidemics, but also in emergent countries because of changes in eating habits.

In diabetic patients, atherosclerosis develops earlier than in other subjects and accounts for excessive morbidity and mortality [1]. Epidemiological studies have shown that cardiovascular diseases are the first cause of morbidity and mortality in patients with type 2 diabetes: coronary artery disease is . . . [Full Text of this Article]


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A. CHATZIGEORGIOU, A. HALAPAS, K. KALAFATAKIS, and E. KAMPER
The Use of Animal Models in the Study of Diabetes Mellitus
In Vivo, March 1, 2009; 23(2): 245 - 258.
[Abstract] [Full Text] [PDF]