Copyright © 2006, European Society of Cardiology
Molecular targets of tea polyphenols in the cardiovascular system
Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie Charité – Universitätsmedizin Berlin, CCM, Schumannstr. 20-21, D-10117 Berlin, Germany
* Corresponding author. Tel.: +49 30 450 513153; fax: +49 30 450 513932. Email address: verena.stangl{at}charite.de
Tea-derived polyphenols have attracted considerable attention in the prevention of cancer and cardiovascular diseases. In comparison to tumour cells, the elucidation of their molecular targets in cardiovascular relevant cells is still at the beginning. Although promising experimental and clinical data demonstrate protective effects for the cardiovascular system, little information is actually available on how these beneficial effects of tea polyphenols are mediated at the cellular level. By affecting the activity of receptor and signal transduction kinases, both catechins and theaflavins – the major ingredients of green and black tea, respectively – exert a variety of cardiovascular beneficial effects. In general, the number and positions of galloyl groups have major influence on the potency of polyphenols. Compared to their broad impact on cellular signal transduction, tea polyphenols reveal little transcriptional effects. However, more detailed and profound analysis of molecular actions in different cells of the cardiovascular system is necessary before safe clinical use of tea polyphenols for treatment of cardiovascular diseases will become possible.
KEYWORDS Tea; Polyphenols; Catechins; Theaflavins; Cardiovascular; Atherosclerosis; Molecular
Time for primary review 27 days
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  H. M. Piper, D. Garcia-Dorado, and E. A. Martinson Monitoring the success of articles: a look back and a look ahead Cardiovasc Res, December 1, 2008; 80(3): 321 - 323. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lorenz, N. Hellige, P. Rieder, H.-T. Kinkel, C. Trimpert, A. Staudt, S. B. Felix, G. Baumann, K. Stangl, and V. Stangl Positive inotropic effects of epigallocatechin-3-gallate (EGCG) involve activation of Na+/H+ and Na+/Ca2+ exchangers Eur J Heart Fail, May 1, 2008; 10(5): 439 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Dreger, M. Lorenz, A. Kehrer, G. Baumann, K. Stangl, and V. Stangl Characteristics of Catechin- and Theaflavin-Mediated Cardioprotection Experimental Biology and Medicine, April 1, 2008; 233(4): 427 - 433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wolfram Effects of Green Tea and EGCG on Cardiovascular and Metabolic Health J. Am. Coll. Nutr., August 1, 2007; 26(4): 373S - 388S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Mann, D. J. Rowlands, F. Y.L. Li, P. de Winter, and R. C.M. Siow Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression Cardiovasc Res, July 15, 2007; 75(2): 261 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Napoli, W. C. Stanley, and L. J. Ignarro Nutrition and cardiovascular disease: Putting a pathogenic framework into focus Cardiovasc Res, January 15, 2007; 73(2): 253 - 256. [Full Text] [PDF]
|
|
|
|
|
|
H. Yamada and H. Watanabe Tea polyphenols in preventing cardiovascular diseases Cardiovasc Res, January 15, 2007; 73(2): 439 - 440. [Full Text] [PDF]
|
|