Skip Navigation

Cardiovascular Research 2007 73(2):298-309; doi:10.1016/j.cardiores.2006.08.018
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by von Haehling, S.
Right arrow Articles by Anker, S. D
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by von Haehling, S.
Right arrow Articles by Anker, S. D
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2006, European Society of Cardiology

Nutrition, metabolism, and the complex pathophysiology of cachexia in chronic heart failure

Stephan von Haehlinga,*, Wolfram Doehnerb and Stefan D Ankera,b

aDepartment of Clinical Cardiology, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
bDivision of Applied Cachexia Research, Department of Cardiology, Charité Medical School, Campus Virchow-Klinikum, Berlin, Germany

* Corresponding author. Tel.: +44 20 7351 8127; fax: +44 20 7351 8733. Email address: stephan.von.haehling{at}web.de

Chronic heart failure is a complex catabolic state that carries a devastating prognosis. The transition from stable disease to cardiac cachexia is not well understood. Mechanisms that maintain the wasting process involve neurohormones and pro-inflammatory cytokines, which contribute to an imbalance in anabolic and catabolic pathways. A decrease in food intake alone rarely triggers the development of a wasting process, but dietary deficiencies in micronutrients and macronutrients contribute to the progression of the disease. Malabsorption from the gut as a result of bowel wall edema and decreased bowel perfusion also plays an important role. This article describes the complex interplay of hormonal systems in energy balance in patients with chronic heart failure as well as other factors such as malabsorption and dietary deficiencies that contribute to the wasting process. Finally, therapeutic approaches are discussed. These include dietary advice, ongoing studies, and future possibilities.

KEYWORDS Cachexia; Heart failure; Nutrition; Catabolism

Time for primary review 23 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CirculationHome page
B. Riegel, D. K. Moser, S. D. Anker, L. J. Appel, S. B. Dunbar, K. L. Grady, M. Z. Gurvitz, E. P. Havranek, C. S. Lee, J. Lindenfeld, et al.
State of the Science: Promoting Self-Care in Persons With Heart Failure: A Scientific Statement From the American Heart Association
Circulation, September 22, 2009; 120(12): 1141 - 1163.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
P. Aukrust, T. Ueland, L. Gullestad, and A. Yndestad
Testosterone: a novel therapeutic approach in chronic heart failure?
J. Am. Coll. Cardiol., September 1, 2009; 54(10): 928 - 929.
[Full Text] [PDF]

Home page
 Eur J Heart FailHome page
D. A. Pascual-Figal, J. C. Bonaque, B. Redondo, C. Caro, S. Manzano-Fernandez, J. Sanchez-Mas, I. P. Garrido, and M. Valdes
Red blood cell distribution width predicts long-term outcome regardless of anaemia status in acute heart failure patients
Eur J Heart Fail, September 1, 2009; 11(9): 840 - 846.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
I. Tracchi, G. Ghigliotti, M. Mura, S. Garibaldi, P. Spallarossa, C. Barisione, V. Boasi, M. Brunelli, L. Corsiglia, A. Barsotti, et al.
Increased neutrophil lifespan in patients with congestive heart failure
Eur J Heart Fail, April 1, 2009; 11(4): 378 - 385.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Kalantar-Zadeh, D. L. Regidor, C. P. Kovesdy, D. Van Wyck, S. Bunnapradist, T. B. Horwich, and G. C. Fonarow
Fluid Retention Is Associated With Cardiovascular Mortality in Patients Undergoing Long-Term Hemodialysis
Circulation, February 10, 2009; 119(5): 671 - 679.
[Abstract] [Full Text] [PDF]

Home page
 Nutr Clin PractHome page
S. P. Dunn, B. Bleske, M. Dorsch, T. Macaulay, B. Van Tassell, and O. Vardeny
Nutrition and Heart Failure: Impact of Drug Therapies and Management Strategies
Nutr Clin Pract, February 1, 2009; 24(1): 60 - 75.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. T. Steffen, S. J. Lees, and F. W. Booth
Anti-TNF treatment reduces rat skeletal muscle wasting in monocrotaline-induced cardiac cachexia
J Appl Physiol, December 1, 2008; 105(6): 1950 - 1958.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. L. Birkenfeld, P. Budziarek, M. Boschmann, C. Moro, F. Adams, G. Franke, M. Berlan, M. A. Marques, F. C.G.J. Sweep, F. C. Luft, et al.
Atrial Natriuretic Peptide Induces Postprandial Lipid Oxidation in Humans
Diabetes, December 1, 2008; 57(12): 3199 - 3204.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
H. M. Piper, D. Garcia-Dorado, and E. A. Martinson
Monitoring the success of articles: a look back and a look ahead
Cardiovasc Res, December 1, 2008; 80(3): 321 - 323.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
S. J. Pocock, J. J.V. McMurray, J. Dobson, S. Yusuf, C. B. Granger, E. L. Michelson, J. Ostergren, M. A. Pfeffer, S. D. Solomon, S. D. Anker, et al.
Weight loss and mortality risk in patients with chronic heart failure in the candesartan in heart failure: assessment of reduction in mortality and morbidity (CHARM) programme
Eur. Heart J., November 1, 2008; 29(21): 2641 - 2650.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Authors/Task Force Members, K. Dickstein, A. Cohen-Solal, G. Filippatos, J. J.V. McMurray, P. Ponikowski, P. A. Poole-Wilson, A. Stromberg, D. J. van Veldhuisen, D. Atar, et al.
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)
Eur. Heart J., October 1, 2008; 29(19): 2388 - 2442.
[Full Text] [PDF]

Home page
 Eur J Heart FailHome page
K. Dickstein, A. Cohen-Solal, G. Filippatos, J. J.V. McMurray, P. Ponikowski, P. A. Poole-Wilson, A. Stromberg, D. J. van Veldhuisen, D. Atar, A. W. Hoes, et al.
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)
Eur J Heart Fail, October 1, 2008; 10(10): 933 - 989.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Kozakova, E. Muscelli, A. Flyvbjerg, J. Frystyk, C. Morizzo, C. Palombo, and E. Ferrannini
Adiponectin and Left Ventricular Structure and Function in Healthy Adults
J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2811 - 2818.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
U. Kintscher
Does adiponectin resistance exist in chronic heart failure?
Eur. Heart J., July 2, 2007; 28(14): 1676 - 1677.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C. Napoli, W. C. Stanley, and L. J. Ignarro
Nutrition and cardiovascular disease: Putting a pathogenic framework into focus
Cardiovasc Res, January 15, 2007; 73(2): 253 - 256.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.