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Cardiovascular Research 2007 73(1):249-250; doi:10.1016/j.cardiores.2006.11.011
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Copyright © 2006, European Society of Cardiology

Reply: Does the adenosine A2A receptor stimulate the ryanodine receptor?

Leif Hove-Madsena,*, Cristina Prat-Vidala, Anna Llacha, Francisco Ciruelab, Vicent Casadób, Carme Lluisb, Antoni Bayes-Genisa, Juan Cincaa and Rafael Francob

aCell Physiology Laboratory, Cardiology Department, Institut Català de Ciències Cardiovasculars, Hospital de la Santa Creu i Sant Pau, St Antoni Ma. Claret 167, 08025 Barcelona, Spain
bDepartment of Biochemistry and Molecular Biology, Universitat de Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain

* Corresponding author. Tel.: +34 935565620; fax: +34 935565603. Email address: lhove@santpau.es

Received 3 November 2006; accepted 9 November 2006

The first 10% of the full text of this article appears below.

In our paper on the expression and function of the adenosine A2A receptor (A2AR) in human atrial myocytes [1], we show that agonist stimulation of this receptor induces a protein kinase A (PKA)-dependent increase in the frequency of calcium sparks and spontaneous calcium waves. We therefore investigated whether A2AR stimulation affected the L-type calcium current, sarcoplasmic reticulum . . . [Full Text of this Article]


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