Skip Navigation

Cardiovascular Research 2007 73(1):10-18; doi:10.1016/j.cardiores.2006.09.003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ventura-Clapier, R.
Right arrow Articles by Bigard, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ventura-Clapier, R.
Right arrow Articles by Bigard, X.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2006, European Society of Cardiology

Beneficial effects of endurance training on cardiac and skeletal muscle energy metabolism in heart failure

Renée Ventura-Clapiera,*, Bertrand Mettauerb,c and Xavier Bigardd

aINSERM U-769, Université Paris-Sud, 5 rue J-B Clément, F-92296, Châtenay-Malabry, France
bDépartement de Physiologie, CHRU Strasbourg, F-67091 France
cService de Cardiologie, Hôpitaux Civils de Colmar, F-68024 France
dCentre de Recherches du Service de Santé des Armées, F-38702 La Tronche Cedex, France

* Corresponding author. Tel.: +331 46 83 57 62; fax: +331 46 83 54 75. Email address: renee.ventura{at}cep.u-psud.fr

As endurance training improves symptoms and quality of life and decreases mortality rate and hospitalization, it is increasingly recognized as a beneficial practice for heart failure (HF) patients. However, the mechanisms involved in the beneficial effects of exercise training are far from being understood and need further evaluation. Independent of hemodynamics effects, exercise training participates in tissue remodeling. While heart failure induces a generalized metabolic myopathy, adaptation to endurance training mainly improves energetic aspects of muscle function. In the present review, after presenting the main characteristics of cardiac and skeletal muscle energy metabolism and the effects of exercise training, we will discuss the evidence for the beneficial effects of endurance training on cardiac and skeletal muscle oxidative metabolism and intracellular energy transfer in HF.

These beneficial effects of exercise training seen in heart failure patients are also relevant to other chronic diseases (chronic obstructive pulmonary disease, diabetes, and obesity) and even for highly sedentary or elderly individuals [Booth F.W., Chakravathy M.V., Spangenburg E.E. Exercise and gene expression: physiological regulation of the human genome through physical activity. J Physiol (Lond) 2002;543:399–411][1]. Physical rehabilitation is thus a major health issue for populations in industrialized countries.

KEYWORDS Energy metabolism; Mitochondria; Heart failure; Heart; Skeletal muscle; Creatine kinase; Endurance training; Mitochondrial biogenesis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
R. Ventura-Clapier, A. Garnier, and V. Veksler
Transcriptional control of mitochondrial biogenesis: the central role of PGC-1{alpha}
Cardiovasc Res, July 15, 2008; 79(2): 208 - 217.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.