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Cardiovascular Research 2006 72(3):359-360; doi:10.1016/j.cardiores.2006.09.017
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Copyright © 2006, European Society of Cardiology

Enhancement of new vessel formation by Angiopoietin-2/Tie2 signaling in endothelial progenitor cells: A new hope for future therapy?

Kou-Gi Shyu*

Division of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan

* Division of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. Tel.: +886 2 2833 2211; fax: +886 2 2836 5775. Email address: shyukg@ms12.hinet.net

Received 19 September 2006; accepted 25 September 2006

The first 10% of the full text of this article appears below.

See article by Kim et al. [6] (pages 394–402) in this issue.

The Tie2/angiopoietin pathway is crucial for angiogenesis, blood vessel maturation, and vascular endothelial integrity. The ligands for Tie2 are the angiopoietins, of which angiopoietin-1 (Ang1) and Ang2 have been the most studied. Suppression of plasma leakage, inhibition of vascular inflammation, and prevention of endothelial death are the three widely accepted vascular protective functions for Ang1 [1], the first ligand identified for the Tie2 receptor. However, the role of Ang2, a relative of Ang1 identified by homology screening, remains less clear, because Ang2 exhibits context-dependent behavior. Ang2 can . . . [Full Text of this Article]


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