Copyright © 2006, European Society of Cardiology
The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart
aDepartment of Biochemistry and Molecular Biology, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany
bDepartment of Anatomy and Embryology, University of Göttingen, Kreuzbergring 36, D-37075 Göttingen, Germany
* Corresponding author. Tel.: +49 731 500 23283; fax: +49 731 500 23277. Email address: michael.kuehl{at}uni-ulm.de
The heart is one of the first organs to function in the developing embryo. Vertebrate heart development can be subdivided into different phases, e.g. specification of myo- and endocardial progenitor cells during the establishment of heart-forming fields within the anterior lateral plate mesoderm, formation of the linear heart tube by merging of the paired heart-forming fields in front of the foregut, looping of the heart tube and transformation of the tubular embryonic heart into the four-chambered heart. The molecular mechanisms underlying these processes are phylogenetically remarkably conserved and involve the activation of specific transcriptional programs by different extracellular growth factors. In this review, we will focus on the functions of the Wnt family of growth factors in normal cardiac development and in tissue remodelling in the mature heart under pathological conditions.
KEYWORDS Wnt; Frizzled; Cardiac development; Cardiac specification; Cardiac morphogenesis; Cardiac remodelling
Time for primary review 22 days
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