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Cardiovascular Research 2006 72(1):9-17; doi:10.1016/j.cardiores.2006.06.004
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Copyright © 2006, European Society of Cardiology

Vascular smooth muscle cell senescence in atherosclerosis

Isabelle Gorenne, Mary Kavurma, Stephen Scott and Martin Bennett*

Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK

* Corresponding author. Tel.: +44 1223 331504; fax: +44 1223 331505. Email address: mrb{at}mole.bio.cam.ac.uk

Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo. This review summarises the evidence for VSMC senescence in atherosclerosis, and outlines the mechanisms and triggers leading to their senescence.

KEYWORDS Atherosclerosis; Vascular smooth muscle; Cell senescence; Ageing

Time for primary review 23 days


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