Skip Navigation

Cardiovascular Research 2006 71(4):642-651; doi:10.1016/j.cardiores.2006.05.005
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Fandrey, J.
Right arrow Articles by Gassmann, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fandrey, J.
Right arrow Articles by Gassmann, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2006, European Society of Cardiology

Regulating cellular oxygen sensing by hydroxylation

Joachim Fandreya,*, Thomas A. Gorrb and Max Gassmannb

aInstitut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122 Essen, Germany
bInstitute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland

* Corresponding author. Tel./fax: +49 201 723 4600/4648. Email address: joachim.fandrey{at}uni-due.de

Oxygen homeostasis under conditions of limited O2 supply requires hypoxia-dependent gene regulation. The transcription factor complex hypoxia-inducible factor 1 (HIF-1) has been recognized as the master regulator that mediates the adaptational genetic response to ensure restoration of energy supply. This review will focus on the recent advances in understanding the hypoxia-induced cellular response with particular respect to cellular O2 sensing for adequate control of HIF-1 activation.

KEYWORDS HIF-1; Hypoxia; Hypoxia-induced gene expression

1 PAS: acronym for PER, ARNT, SIM, the first proteins discovered to contain this domain.

Time for primary review 28 days


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Schmid-Brunclik, C. Burgi-Taboada, X. Antoniou, M. Gassmann, and O. O. Ogunshola
Astrocyte responses to injury: VEGF simultaneously modulates cell death and proliferation
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R864 - R873.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Fandrey
Erythropoiesis--once more HIF!
Blood, August 15, 2008; 112(4): 931 - 932.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
U. Berchner-Pfannschmidt, S. Frede, C. Wotzlaw, and J. Fandrey
Imaging of the hypoxia-inducible factor pathway: insights into oxygen sensing
Eur. Respir. J., July 1, 2008; 32(1): 210 - 217.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.