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Cardiovascular Research 2006 71(3):405-407; doi:10.1016/j.cardiores.2006.05.025
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Copyright © 2006, European Society of Cardiology

Post-infarct heart repair with granulocyte-colony stimulating factor: Is it a utopian goal?

Pasquale Pagliaro*

Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Regione Gonzole 10, 10043, Orbassano (TO), Italy

* Tel.: +39 011 6705430; fax: +39 011 9038639. Email address: pasquale.pagliaro@unito.it

Received 15 May 2006; accepted 29 May 2006

The first 10% of the full text of this article appears below.

See article by Misao et al. [16] (pages 455–465) in this issue.

For many years, the regeneration of the myocardium in which cells have been lost as a result of myocardial infarction (MI) and other forms of cardiac pathology has been a utopian goal of cardiologists. Recent experimental studies and early-phase clinical trials supported the possibility of enhancing cardiac repair as an achievable therapeutic target. Yet, disappointing, negative results have been reported both in experimental and clinical studies [1–3]. There can be several reasons for negative results. Certainly, the fact that we do not know the exact physiology of stem cells is one of the reasons.

We do not know yet the ideal cell type: bone marrow stem cells (BMSCs), cardiomyoplasty cardiomyocytes, skeletal myoblasts, and resident . . . [Full Text of this Article]


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