Copyright © 2005, European Society of Cardiology
Caveolins in vascular smooth muscle: Form organizing function
aDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
bDepartment of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
* Corresponding author. Tel.: +1 573 884 6209; fax: +1 573 884 6209. Email address: HardinC{at}missouri.edu
Caveolae are becoming increasingly recognized as an important organizational structure for a variety of signal and energy-transducing systems in vascular smooth muscle (VSM). In this review, we discuss the emerging role of the caveolins in organizing and modulating the basic functions of smooth muscle: contraction, growth/proliferation, and the energetic support systems that support these functions. With clear alterations in cell metabolism and function in VSM with altered caveolin-1 (Cav-1) protein expression and with cardiovascular abnormalities associated with Cav-1 null mice, the caveolin family of proteins may play an important role in the function and dysfunction of VSM.
Time for primary review 28 days
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