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Cardiovascular Research 2006 69(4):808-815; doi:10.1016/j.cardiores.2005.11.024
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Copyright © 2005, European Society of Cardiology

Caveolins in vascular smooth muscle: Form organizing function

Christopher D. Hardina,* and Johana Vallejob

aDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
bDepartment of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA

* Corresponding author. Tel.: +1 573 884 6209; fax: +1 573 884 6209. Email address: HardinC{at}missouri.edu

Caveolae are becoming increasingly recognized as an important organizational structure for a variety of signal and energy-transducing systems in vascular smooth muscle (VSM). In this review, we discuss the emerging role of the caveolins in organizing and modulating the basic functions of smooth muscle: contraction, growth/proliferation, and the energetic support systems that support these functions. With clear alterations in cell metabolism and function in VSM with altered caveolin-1 (Cav-1) protein expression and with cardiovascular abnormalities associated with Cav-1 null mice, the caveolin family of proteins may play an important role in the function and dysfunction of VSM.

Time for primary review 28 days


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