Copyright © 2005, European Society of Cardiology
Involvement of lipid rafts and caveolae in cardiac ion channel function
aDepartment of Medicine and Research Center, Montreal Heart Institute and University of Montreal, 5000 Belanger Street, Montreal, Quebec, Canada H1T 1C8
bDepartment of Pharmacology and Therapeutics, Mc Gill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
* Corresponding author. Montreal Heart Institute, 5000 Belanger St. E., Montreal H1T 1C8. Tel.: +1 514 376 3330; fax: +1 514 376 1355. Email address: stanleynattel{at}aol.com
A variety of lipid microdomains, including caveolae, have been shown to play an important role in both protein targetting and in controlling protein–protein interactions. There is increasing evidence for significant ion channel localization in lipid rafts. Cardiac channel subunits known to localize in lipid rafts include Kv1.4, Kv1.5, Kv2.1, Kv4, Kir2, Kir3, KATP, Nav and Cav subunits. This article reviews what is known about the occurrence and functional significance of cardiac ion channel/lipid raft interactions. Much remains to be learned about this area of potentially enormous importance to cardiac function in health and disease.
KEYWORDS Potassium channel; Caveolae; Connexins; Sodium channel; Calcium channel
Time for primary review 20 days
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