Copyright © 2005, European Society of Cardiology
Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): A critical player in the development of atherosclerosis and related disorders
aDepartments of Internal Medicine and Physiology and Biophysics, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States
bUniversity of Rome Tor Vergata, Rome, Italy
* Corresponding author. Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Slot 532, Little Rock, AR 72205, United States. Tel.: +1 501 686 6724. Email address: MehtaJL{at}uams.edu
LOX-1, a lectin-like 52-kD receptor for oxidized low-density lipoproteins (ox-LDL), is present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by angiotensin II, endothelin, cytokines, and shear stress, all participants in atherosclerosis. This receptor is upregulated in the arteries of hypertensive, dyslipidemic, and diabetic animals. Upregulation of LOX-1 has been identified in atherosclerotic arteries of several animal species and humans, not only on the endothelial lining, but also in the neovasculature of the atherosclerotic plaque, and this receptor is often co-localized with apoptotic cells. Recent studies show upregulation of LOX-1 in the ischemic-reperfused myocardium. LOX-1 inhibition is associated with attenuation of atherosclerosis and associated ischemic injury. LOX-1 may be a novel, exciting target for drug therapy.
KEYWORDS Lipids receptors; LOX-1; Oxidised LDL
Time for primary review 17 days
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