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Cardiovascular Research 2006 69(1):13-14; doi:10.1016/j.cardiores.2005.10.013
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Copyright © 2005, European Society of Cardiology

Dual conductance mode of the TREK-1 channel: A hidden track to mechanoelectric regulation in the heart?

Sung Joon Kim and Yung E. Earm*

Department of Physiology and Biophysics, Seoul National University College of Medicine, 28 Yonkeun-Dong, Chongno-Ku, Seoul 110-799, South Korea

* Corresponding author. Tel.: +82 2 740 8224; fax: +82 2 763 9667. Email address: earmye@snu.ac.kr

Received 23 October 2005; accepted 27 October 2005

The first 10% of the full text of this article appears below.

See article by Li et al. [12] (pages 86–97) in this issue.


   1. The mechano- and lipid-sensitive background K+ channels in heart
 
Two-pore-domain K+ channels (K2P channels) form a novel class of K+ channels identified in various types of cells. K2P channels display constitutive activity at around the resting membrane potential and are sensitively regulated by various physical and chemical factors [1,2]. Among the members of K2P channels, TREK and TRAAK families respond to the widest variety of stimuli including pH, temperature, unsaturated fatty acids, phospholipids, volatile anesthetics, and membrane stretch [1,2]. The mechanical gating of TREK seems to arise from the direct interaction between the membrane phospholipid and the sensor domain . . . [Full Text of this Article]


   2. Physiological role of TREK-1 in heart
 

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