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Cardiovascular Research 2005 68(3):387-393; doi:10.1016/j.cardiores.2005.09.016
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Copyright © 2005, European Society of Cardiology

Predominant fusion of bone marrow-derived cardiomyocytes

Jacob Andradea, Jason T. Lama, Monica Zamoraa,e, Chengqun Huanga, Diego Francob, Noemi Sevillac, Peter J. Gruberd, Jonathan T. Lua and Pilar Ruiz-Lozanoa,e,*

aInstitute of Molecular Medicine, University of California, San Diego, United States
bDepartment of Experimental Biology, University of Jaen, Spain
cCentro de Biologia Molecular, Madrid, Spain
dChildrens Hospital, Philadelphia, United States
eThe Burnham Institute, 10901 North Torrey Pines Rd., La Jolla, CA 92037, United States

* Corresponding author. The Burnham Institute, 10901 North Torrey Pines Rd., La Jolla, CA 92037, United States. Tel.: +1 858 646 3100x3277; fax: +1 858 713 7123. Email address: plozano{at}burnham.org

Objectives: Here we address the capacity of bone marrow-derived cells (BMDCs) to trans-differentiate into mature myocytes under the physiological stimulus of exercise training.

Methods: For this purpose, we have transplanted bone marrow from mice ubiquitously expressing enhanced green fluorescence protein (eGFP) into host mice that have been subjected to a prolonged program of exercise.

Results: In all successful bone marrow reconstitutions (greater than 80%), we observed rare but consistent events of bone marrow-derived cardiomyocytes, the frequency of which was unchanged upon exercise training. We have further determined whether these recruited myocytes are a product of trans-differentiation or fusion by the use of a genetic system that distinguishes cell fusion from trans-differentiation in a single-cell assay.

Conclusions: We concluded that both in the unchallenged mouse and in the trained specimens, fusion is the most prominent mechanism by which bone marrow-derived cells are observed in the myocyte compartment.

KEYWORDS Bone marrow-derived cell; Heart failure; Cardiomyocytes

Time for primary review 10 days


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