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Cardiovascular Research 2005 67(4):747-748; doi:10.1016/j.cardiores.2005.06.002
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Copyright © 2005, European Society of Cardiology

Room for both tyrosine nitration and cysteine nitrosylation to regulate NF{kappa}B activity, but perhaps only one modification at a time

Steven S. Grossa,* and Yoshiyuki Hattorib

aDepartment of Pharmacology, Weill Medical College of Cornell University, USA
bDepartment of Endocrinology & Metabolism, Dokkyo University School of Medicine, Japan

* Corresponding author. Tel.: +1 212 746 6257; fax: +1 212 746 8258. Email address: ssgross@med.cornell.edu

Received 15 June 2005;
The first 10% of the full text of this article appears below.

In their letter to the editor, Biswas and Lopes de Faria expressed concern that a recent report by Park et al. in Molecular and Cellular Proteomics [1] appears to contradict our earlier report showing that NO, but not peroxynitrite, inhibits NF{kappa}B-mediated gene activation [2]. Careful consideration of the respective studies should allay the reader's concern–there is no disagreement between data presented in these two reports. Whereas our study probes the physiological process by which NO prevents NF{kappa}B from becoming activated in vascular cells (i.e., in response to immunostimulants), Park examines how an NO-donor might turn off NF{kappa}B in a pathophysiological setting where it is . . . [Full Text of this Article]


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