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Cardiovascular Research 2005 67(4):745-746; doi:10.1016/j.cardiores.2005.06.003
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Copyright © 2005, European Society of Cardiology

Does peroxynitrite sustain nuclear factor-{kappa}B?

Subrata K. Biswas* and Jose B. Lopes de Faria

Laboratorio de Fisiopatologia Renal, NMCE, Division of Nephrology, FCM, University of Campinas, Cidade Universitaria, Campinas 13083-970, Sao Paulo, Brazil

* Corresponding author. Tel.: +55 19 37887499; fax: +55 19 37887366. Email address: subrata@fcm.unicamp.br

Received 4 April 2005; accepted 15 June 2005

The first 10% of the full text of this article appears below.

We read with interest the article by Hattori et al. [1] published in Cardiovascular Research in July, 2004. The authors showed almost complete suppression of lipopolysaccharide (LPS)-induced nuclear factor-{kappa}B (NF-{kappa}B) activation by nitric oxide (NO) in vascular smooth muscle cells. They showed that this effect of NO was not mediated through the second messenger cGMP or through peroxynitrite, an NO-derived reactive nitrogen species (RNS). Instead, the authors demonstrated sustained activation of LPS-induced NF-{kappa}B by peroxynitrite. Although . . . [Full Text of this Article]


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