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Cardiovascular Research 2005 66(3):430-432; doi:10.1016/j.cardiores.2005.04.001
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Copyright © 2005, European Society of Cardiology

Supraventricular pacemaker activity in the canine heart: Contributions from HCN channels in control conditions and in a model of heart failure

Wayne R. Giles

Departments of Bioengineering and Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, United States

Received 6 April 2005;

The first 10% of the full text of this article appears below.

See also article by Zicha et al.[1] (the Nattel Research Group) (pages 472–481) in this issue.

An interesting and clearly presented paper from the Nattel Research Group [1] in this volume of Cardiovascular Research provides new evidence for the expression of three isoforms of hyperpolarization-activated cyclic nucleotide-gated ion channels (HCN) in the sinoatrial node and atria of the adult canine heart. These measurements have been made under control conditions, and in the setting of a model of congestive heart failure–tachycardia-induced sinus node dysfunction.

A major premise of this study is that although it is well-known that transmembrane ionic currents generated by HCN ion channels contribute to pacemaker activity, there appear to be significant species differences, and little information on . . . [Full Text of this Article]


   1. Previous findings
 

   2. The role of If in normal pacemaker function
 

   3. If in heart failure: ectopic supraventricular pacemaker activity
 

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