Copyright © 2004, European Society of Cardiology
Biophysical basis for monophasic action potential
Gordon K. Moe Scholar, Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, NY 13501-1787, United States
* Corresponding author. Tel.: +1 315 735 5648; fax: +1 315 735 5648. Email address: ca@mmrl.edu
Received 14 December 2004; accepted 22 December 2004
| The first 150 words of the full text of this article appear below. |
We welcome Dr. Franz's comments relative to our recent publication dealing with the monophasic action potential (MAP) [1]. We agree and fully appreciate the fact that the Franz contact electrode technique has been successfully used for over 20 years by Dr. Franz and other investigators. This success stems from the fact that the two electrodes of the contact catheter are relatively close to each other so that their combined field of view is fairly localized. However, we do not agree that this success can be used as an argument against our conclusion that it is not the tip electrode that records the MAP. Our study investigated the physical principles behind the MAP recording. We started with a simple definition of voltage as the difference of potential between two points or two electrodes. To determine which of these two potentials carries time-dependent information, we placed the two electrodes at sites
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